Pitfalls of Diagnosis of Extraprostatic Extension in Prostate Adenocarcinoma

Extra prostatic extension (EPE) is of the important features to evaluate in pathological assessment of radical prostatectomy specimens. Despite the uncomplicated definition of presence of neoplastic glands outside the prostatic boundary, diagnosing EPE is not always straightforward, the main reason being absence of true capsule around prostate gland. Other confounding findings include intracapsular incision, desmoplastic reaction, intraprostatic fat, tumor displacement (pseudo invasion) and benign mimickers. This study reviews different situations obscuring the diagnosis of EPE and is the first study illustrating pseudo invasion in prostate.